Pathogenetic Effects of Bacteria of the Genus <i>Desulfovibrio</i>. Experimental Study. Part One: Iron Metabolism

The aim of the work was to study specific systemic effect sulfate-reducing bacteria genus Desulfovibrio on organism systems through creating an experimental model intragastric bacterial invasion against background dysbiotic conditions rodent gastrointestinal tract. Materials and methods . conducted Wistar rats. Intestinal dysbiosis modeled with help antibiotics, amoxicillin metronidazole. Typical strain desulfuricans subsp. VKM B-1799 T used as infectious agent. Results discussion As a result experiment performed, during period acute infection (on day 15 experiment), direct correlation between concentration injected D. suspension serum iron level observed: higher agent dose, lower concentration. During phase remote effects (day 38 inverse concentrations in intestines rodents revealed: when infecting increased from 10 3 CFU/g higher, decreased 43.5 μmol/l 38.5 μmol/l. When comparing transferrin unsaturated binding capacity (UIBC), increase those parameters observed all groups rats both long-term effects, percentage saturation decreased, indicating occurrence deficiency exposure promotes colonization by opportunistic flora, including sp. Changes metabolism markers animals infestation above ability this microorganism bind into unavailable form suggest that are one key etiological factors anemia.